Cannabinoids in cancer treatment: Therapeutic potential and legislation PMC

In some cases of exocrine pancreatic cancer, a patient will receive radiation therapy. Doctors often use radiation therapy to supplement surgery or replace it. Radiation therapy can reduce the chance of cancer returning or shrink cancer cells. THC oil extracts have been used by patients with epilepsy that are not responding well to medications. They also help cancer patients suffering from pain due to chemotherapy.

• Visuals Online is a collection of more than 3,000 scientific images.
• Smoked marijuana has also helped improve food intake in HIV patients in studies.
• It can be consumed orally or smoked, and is also vaporized, or ‘vaped’.
• Therefore, it is of utmost importance that your medication is as pathogen-free as possible – no fungus, mold, bacteria, or other microbes that may cause an infection.

Back pain is one of the most common forms of both acute and chronic pain. Acute back pain tends to be caused by an injury, such as by falling or lifting something heavy. https://hiwildflower.com/ Chronic back pain is that which lasts more than three months and is often caused by a ruptured or bulging disc, arthritis, osteoporosis, scoliosis, or nerve pain.

Within most cells there is a cell nucleus, numerous mitochondria , and various other organelles in the cytoplasm. As ceramide starts to accumulate, turning up the Sphingolipid Rheostat, it increases the mitochondrial membrane pore permeability to cytochrome c, a critical protein in Why You Can’T Buy CBD Gummies On Amazon energy synthesis. Cytochrome c is pushed out of the mitochondria, killing the source of energy for the cell. Based in Seattle, Washington, Cheyann is a social media influencer and the creator behind the popular Instagram account @cheymarie_fit and YouTube channel Cheyann Shaw.

Medical Studies Proving Cannabis Cures Cancer

Ms. Blansky said she does not know if marijuana or cannabis oils helped put her Hodgkin’s lymphoma into remission over a year ago, although she feels their use helped her cope with her treatment. She described her goal in speaking before the symposium as “trying to change the narrative in some way,” to debunk myths about cannabis products as gateway drugs and to help to decriminalize their use in people with cancer. This symptom can keep cancer patients from living their lives to the fullest. Medical marijuana is proven to curb feelings of nausea and keep patients from vomiting. Whether it’s caused by chemo or the disease itself, cannabis can help. The presence of THC in a strain has been shown effective to treat this side effect.

The FDA has not approved Cannabis or cannabinoids for use as a cancer treatment . To see how this works we visualize the cannabinoid as a three dimensional molecule, where one part of the molecule is configured to fit the nerve or immune cell receptor site just like a key in a lock. There are at least two types of cannabinoid receptor sites, CB1 and CB2 . In general CBD Oil For Workout Recovery CB1 activates the CNS messaging system, and CB2 activates the immune system, but it’s much more complex than this. Another factor here is that sativa is dominated by THC cannabinoids, and indica is predominately CBD . First let’s look at what keeps cancer cells alive, then we will come back and examine how the cannabinoids CBD and THC unravels cancer’s aliveness.

The amount of THC in marijuana has been increasing steadily in recent decades, creating more harmful effects in some people. Marijuana use has also been linked to other mental health problems, such as depression, anxiety, and suicidal thoughts among teens. The popularity of edibles also increases the chance of harmful reactions. Therefore, people may consume more to feel the effects faster, leading to dangerous results.



Information about using the illustrations in this summary, along with many other cancer-related images, is available in Visuals Online, a collection of over 2,000 scientific images. Some of the reference citations in this summary are accompanied by a level-of-evidence designation. These designations are intended to help readers assess the strength of the evidence supporting the use of specific interventions or approaches. The PDQ Integrative, Alternative, and Complementary Therapies Editorial Board uses a formal evidence ranking system in developing its level-of-evidence designations.

Other studies have also shown the antitumor effect of cannabinoids (i.e., CBD and THC) in preclinical models of breast cancer. For patients with AIDs or those undergoing chemotherapy for cancer, nausea, vomiting, and the resulting weight loss can be devastating. In multiple clinical trials, THC has been shown effective at treating all of these conditions. In fact, is it necessary to use moisturizer after cbd serum it’s so effective that pharmaceutical companies have harnessed this knowledge to create dronabinol, a synthetic THC that’s regularly prescribed to patients with cancer or AIDs. It’s important to remember that marijuana is a psychoactive drug and should not be used as a replacement for proven medical treatments without the guidance of a healthcare provider.

Cannabinoids in cancer treatment: Therapeutic potential and legislation

Cannabis and Pregnancy – An overview of what research says about the effects of consuming marijuana while pregnant. Cannabis and Depression – A guide to marijuana and depression, including CBD for depression. Chemotherapy often comes with a whole host of unpleasant side effects – and with those side effects come an entire list of medications. Images in this summary are used with permission of the author, artist, and/or publisher for use within the PDQ summaries only. Permission to use images outside the context of PDQ information must be obtained from the owner and cannot be granted by the National Cancer Institute.



For example, some patients report that the effects of dronabinol are much more powerful than psychoactive THC side effects, leaving them unable to function after just one dose. With nabiximols, nearly a quarter of patients experience dizziness see through dresses and lingerie after taking the drug. Researchers also have hope that THC and other cannabinoids may prove useful in treating diseases like Alzheimers and dementia, Tourette syndrome, Huntington’s disease, PTSD, and Parkinson’s disease, among others.

Some medical marijuana laws are broader than others, and there is state-to-state variation in the types of medical conditions for which treatment is allowed. Mounting evidence shows ‘cannabinoids’ in marijuana slow cancer growth, inhibit formation of new blood cells that feed a tumor, and help manage pain, fatigue, nausea, and other side effects. Nabilone (Cesamet®) is a synthetic cannabinoid that acts much like THC. It can be taken by mouth to treat nausea and vomiting caused by cancer chemotherapy when other drugs have not worked. Different compounds in marijuana have different actions in the human body. For example, delta-9-tetrahydrocannabinol seems to cause the “high” reported by marijuana users, and also can help relieve pain and nausea, reduce inflammation, and can act as an antioxidant.

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All these cannabinoids are activated through the heating process and produce an aroma that ranges from earthy pine notes to tropical fruit flavor… And deliver quite the punch. In two different sizes – 15 and how to choose cbd vape pens 30 ml – with concentrations from 750 mg to 3,000 mg of the purest richest cannabinoids in the market. To relax and chill out, and products like this Delta 10 tincture are designed to help you do just that.

NCI’s PDQ® Evidence-based Summaries

Therefore, in cancer therapy, it is very important to consider the risk of acceleration of tumor growth due to the concentration-dependent proliferative potential of cannabinoids . Has been used as an herbal remedy for centuries and cbd shatter is the most important source of phytocannabinoids. The endocannabinoid system consists of receptors, endogenous ligands and metabolizing enzymes, and plays an important role in different physiological and pathological processes.

In some places, approval for medical cannabis is granted for diseases that are still being researched, while in others, more evidence is needed before those conditions will be added to the list. While research has suggested that THC may be helpful for many different medical conditions, scientists are quick to note that the compound isn’t a cure-all and that more evidence is needed to confirm its benefits. There have been a number of promising trials that look to cannabis as a potential treatment for many different diseases. They do this by mimicking natural brain chemicals and plugging themselves into cannabinoid receptors in the brain. THC, for example, mimics the effects of a neurotransmitter called anandamide that creates pleasure, kills pain, and eliminates depression. At this time, the US Drug Enforcement Administration lists marijuana and its cannabinoids as Schedule I controlled substances.

Marijuana Fights Tumors in Cancer Patients

The study tracked the patients’ opiate use, seeing how it changed as some of the 34 states legalized medical cannabis over the five-year span. Cannabis has been used medicinally for centuries to improve mood and productivity. In recent years, cannabis has also been shown to be effective in treating various other conditions like anxiety, cancer, and chronic pain. It’s difficult for me to say which type of weed is “best” as the effects of marijuana can vary greatly depending on the individual. Different strains of marijuana can have different effects on different people, so it’s best to do some research and talk to others who have experience with different types of weed to find out which one may be best for you.

Cannabis and cannabinoids have been studied in the treatment of anxiety. Cannabis and cannabinoids have been studied as ways to manage side effects of cancer and cancer therapies. Clinical trials are studying a medicine made from an extract of Cannabis that contains specific amounts of cannabinoids. By federal law, possessing Cannabis Clootie Recipe (with CBD) is illegal in the United States unless it is used in approved research settings. However, a growing number of states, territories, and the District of Columbia have passed laws to legalize medical and/or recreational marijuana. By federal law, possessing Cannabis is illegal in the United States outside of approved research settings.

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Perez-Gomez E, Andradas C, Blasco-Benito S, Caffarel MM, Garcia-Taboada E, Villa-Morales, et al. Role of cannabinoid receptor CB2 in HER2 pro-oncogenic signaling in breast cancer. Birdsall SM, Birdsall TC, Tims LA. The use of medical marijuana in cancer. Although still strict, the legislation on the use of cannabis-based medications has been improved, especially following the promising results of related basic research. The Republic of Slovenia established a legal basis for the use of cannabinoids in the years 2016 and 2017.

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There are no studies in people of the effects of marijuana oil or hemp oil. A few studies have found that inhaled marijuana can be helpful treatment of neuropathic pain . Scientists have identified many biologically active components in marijuana. The two best studied components are the chemicals delta-9-tetrahydrocannabinol , and cannabidiol .

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One example would be if you are experiencing inflammation, yet you are wanting to go about your day normally, without the psychotropic effects of THC. In this situation, a high-CBD low-THC strain can provide relief without much of an impact on mental function. CBD does not directly bind to the receptors found in the endocannabinoid system but rather works to modulate the effects of the endocannabinoids as well as working as a CB1 receptor antagonist.

Cannabinoid receptors aren’t only located the brain; certain ones can also be found throughout the body. THC absorbed through the skin in creams and balms can interact with these receptors to provide pain relief. It can’t enter the bloodstream this way, however, and won’t create a high. Reports of these medications not working as well as cannabis hhc no cap only serve to confirm the theory of the entourage effect. It may be that whole-plant marijuana that contains the full spectrum of of cannabinoids and terpenes simply works better than drugs that only contain one or two of these compounds. Multiple sclerosis causes the muscles to cramp up and become stiff, which results in aches and intense pain.

Does smoking marijuana cause cancer?

Extracts such as hashish and hash oil typically contain more THC than high potency cannabis infructescences. There is sufficient evidence of reproductive health harms from cannabis that its use when trying to conceive, during pregnancy, and while breastfeeding, is not advisable. According to DSM-V criteria, 9% of those who are exposed to cannabis develop cannabis use disorder, compared to 20% for cocaine, 23% for alcohol and 68% for nicotine. Cannabis use disorder in the DSM-V involves a combination of DSM-IV criteria for cannabis abuse and dependence, plus the addition of craving, without the criterion related to legal troubles. Cannabis is suspected of being a potential, and under-reported, contributory factor or direct cause in cases of sudden death, due to the strain it can place on the cardiovascular system.

Canadian diagnosed with terminal cancer has been waiting over a year to access medical psilocybin

When you pick a consumption method, you must consider your health problems, reaction to weed, and personal preferences. The field of medical marijuana research is still relatively new and exciting. We’ve studied it for years, but the law has limited our ability to research it like other topics. As laws and opinions on weed change, so will our resources for medical marijuana research. Among all cancer cases in the U.S., about three percent involve pancreatic cancer.

Scientists are continuing to work to see if THC may prove to be a good preventative drug for individuals who are at a high risk of brain injury . The first active ingredient he and his team discovered in cannabis was CBD. While it has some very interesting effects, CBD doesn’t cause vape pen a psychoactive high, so the team kept searching. Over the years, researchers have learned a lot about the effects of THC and its potential uses. The first building block in this huge base of knowledge was laid back in the 1960s by an Israeli scientist named Raphael Mechoulam.

Marijuana and cancer risk

Some strains of cannabis can have as little as 0.3 percent THC by weight. In other strains, THC makes up 20 percent of the weight in a sample. The National Highway Traffic Safety Administration reports that the average THC concentration in marijuana is 1 to 5 percent; in hashish, it is 5 to 15 percent, and in hashish oil, it averages 20 percent. THC in recreational doses of marijuana is highly variable and the lower the THC content in the marijuana, the more the user must consume to produce the desired effects. The use of marijuana may cause problems for younger people, and long-term problems.

In a study that directly compared smoked marijuana with THC, researchers found that both prevented vomiting to a similar degree. Only one in four people in this study of 20 patients achieved complete control of chemotherapy-induced vomiting with cbd paste either drug.6 Each underwent chemotherapy twice during the trial. During one session, patients smoked a marijuana cigarette and swallowed a placebo pill; at the other session they smoked a placebo cigarette and took a pill containing THC.



Cannabis.net sat down with the new ChatGPT AI-powered chat bot taking over the world. Let’s see what ChatGPT has to say about cannabis legalization and marijuana in general. Vapes are not for young people or non-smokers because of possible risks to their health. Edibles are also considered lower risk than smoking as they do not cause lung damage.

Currently, conventional medicine uses Androgen Deprivation Therapy , a widely used cancer protocol for men with prostate cancer. This therapy deprives prostate cells of androgen, thus inhibiting further development. Another study published in Cancer Treatment Reviews shows that CBD hampers tumor growth, angiogenesis, and metastasis and as such, offers new hope as a non-toxic breast cancer therapy . There are also numerous studies on the tetrahydrocannabinol in cannabis, which reveal it is responsible for a multitude of healing properties, including powerful anti-cancer properties. With the advent of the medical marijuana movement in the US, however, more studies are being funded to determine the actual healing potential of this herb. Even in the West, cannabis was the primary pain reliever prescribed by doctors until Aspirin took its place in 1897.

How do people use marijuana?

Now that cannabis is legal in New York and several other states, patients can go through a certifying provider, like Dr. Dr. Raghunathan explains that the cannabis plant contains 108 chemicals, but THC and CBD are more prominent, easier to pull from the plant, and easier to study. THC is the chemical that has a psychoactive component, while CBD does not. Cannabinoids – Exploration of cannabinoids, their effects, and their health benefits.

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It’s difficult to say where the “best” weed is grown, as the effects of marijuana can vary depending on a variety of factors including the strain of the plant, the growing conditions, and the individual using it. Additionally, marijuana is illegal in many places, so it may not be grown openly or advertised as being of a certain quality. In places where marijuana is legal, it may be grown in a variety of locations, from small indoor grow operations to large commercial greenhouses. Ultimately, the quality of marijuana can vary greatly, so it’s important to do research and potentially try out different strains to find the one that works best for you.

This viewpoint stands contrary to the idea of holistic medicine, where you take something in its entirety for medicinal purposes. Unless otherwise noted, all articles focusing on new research are based on studies published in peer-reviewed journals or issued from independent and respected where to buy cbd oil in calderdale uk medical associations, academic groups and governmental organizations. As with any medicine, marijuana may amplify side effects of other medications. It is important to discuss the use of medicines and supplements with a physician and ask about potential side effects or interactions.

Cannabis oils that contain THC may help control nausea and vomiting for people who are going through chemotherapy. There’s also evidence that they can treat pain and improve appetite. Rick Simpson Oil , an oil made from the flowers of the cannabis plant, gets attention online from people who claim it treats cancer.

At best these conditions diminish quality of life; at worst they hasten death. Depending on the type of cancer, 50 to 80 percent of patients will develop cachexia, a disproportionate loss of lean body tissue. Cachexia occurs most often during the final stages of advanced pancreatic, lung, and prostate cancers. Proteins called cytokines, produced by the immune system in response to the tumor, appear to stimulate this wasting cbd bath bombs process. ASCO antiemetic guidelines updated in 2017 state that evidence remains insufficient to recommend medical marijuana for either the prevention or treatment of N/V in patients with cancer who receive chemotherapy or radiation therapy. Three trials have evaluated the efficacy of inhaled Cannabis in chemotherapy-induced N/V.[46-49] In two of the studies, inhaled Cannabis was made available only after dronabinol failure.

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This allows you to access the full potential of the wide array of healthful and anti-inflammatory compounds found in the Cannabis sativa plant. Like the Cannabis sativa extract, studies have why the skin care industry is shifting to natural cbd products found that exceeding the optimal dose of CBD can lead to a reduction in efficacy. In a study examining the effect of CBD on anxiety, 100 mg and 900 mg were not effective, where 300 mg was.

In the case of THC gummies, they are just one of many cannabis-based products on the market, but they too have their dangers. As the medical marijuana industry grows, cultivators are producing strains that can pinpoint specific symptoms. As these symptoms are alleviated, you’ll be able to live a happier and healthier life. Physician Data Query is the National Cancer Institute’s (NCI’s) comprehensive cancer information database. The PDQ database contains summaries of the latest published information on cancer prevention, detection, genetics, treatment, supportive care, and complementary and alternative medicine. The health professional versions have detailed information written in technical language.

RSO is an oil made by washing cannabis buds with a solvent, such as pure light naphtha, and then boiling off the solvent leaving behind the oil. CBD may ease pain, inflammation, and anxiety without causing the high. Even with intensive research, prevention and early detection are still the only effective measures against melanoma. As such, new therapeutic strategies are vital for the management of this devastating disease.

Medical Marijuana eased the pain, gave me back my zest for life and helped me accomplish my goals. Studieshave shown that medical marijuana and the active ingredients within can help limit these feelings of nausea, in addition to helping with appetite. Higher potency cannabis oils provide relief and relaxation for a variety of symptoms and conditions. A related alternative to the gateway hypothesis is the common liability to addiction theory. It states that some individuals are, for various reasons, willing to try multiple recreational substances.

“There have been ten clinical trials on the use of inhaledCannabis in cancer patients that can be divided into two groups. In one group, four small studies assessed antiemetic activity, but each explored a different patient population and chemotherapy regimen. One study demonstrated no effect, the second study showed a positive effect versus placebo, and the report of the third study did not provide enough weed pen information to characterize the overall outcome as positive or neutral. Consequently, there are insufficient data to provide an overall level of evidence assessment for the use of Cannabis for chemotherapy-induced N/V. Apparently, there are no published controlled clinical trials on the use of inhaled Cannabis for other cancer-related or cancer treatment–related symptoms.” NIH National Cancer Institute.

Medical Marijuana and Cancer

Ablation uses extreme temperatures to destroy cancer cells and doesn’t require a stay at the hospital afterward. Embolization involves blocking blood flow to how to vape the affected area to kill off the cancer cells. Before we get into the specifics of pancreatic cancer, it helps to understand exactly how the pancreas works.

Managing cancer symptoms with medical marijuana

The Duquenois–Levine test is commonly used as a screening test in the field, but it cannot definitively confirm the presence of cannabis, as a large range of substances have been shown to give false positives. Researchers at John Jay College of Criminal Justice reported that dietary zinc supplements can mask the presence of THC and other drugs in urine. However, a 2013 study conducted by researchers at the University of Utah School of Medicine refute the possibility of self-administered zinc producing false-negative urine drug tests. Additional desired effects from consuming cannabis include relaxation, a general alteration of conscious perception, increased awareness of sensation, increased libido and distortions in the perception of time and space. At higher doses, effects can include altered body image, auditory and/or visual illusions, pseudohallucinations and ataxia from selective impairment of polysynaptic reflexes.

Solinas M, Massi P, Cinquina V, Valenti M, Bolognini D, Gariboldi M, et al. Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect. Grotenhermen F, Muller-Vahl K. The therapeutic potential of cannabis and cannabinoids.

Medication, which is the typical treatment of choice if a man chooses to explore ADT . Cannabis extract treatment for terminal acute lymphoblastic leukemia with a Philadelphia chromosome mutation. There is no solid evidence to support the claims that RSO can cure cancer directly.

Each trial answers certain scientific questions in order to find new and better ways to help cancer patients. During treatment clinical trials, information is collected about the effects of a new treatment and how well it works. If a clinical trial shows that a new treatment is better than one currently being used, the new treatment may become “standard.” Patients may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment. Nevertheless, most chemotherapy patients probably would not choose marijuana or THC as an antiemetic. Compared with the highly effective agents currently available, marijuana-based versions appear to offer most people only modest relief.

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In 2017, the U.S. was estimated to constitute 90% of the worldwide $9.5 billion legal trade in cannabis. The price or street value of cannabis varies widely depending on geographic area and potency. The main producing countries of cannabis are Afghanistan, Canada, China, Colombia, India, Jamaica, Lebanon, Mexico, Morocco, the Netherlands, Pakistan, Paraguay, Spain, Thailand, Turkey, the United Kingdom, and the United States. In Copenhagen, Denmark in 2014, mayor Frank Jensen discussed possibilities for the city to legalize cannabis production and commerce.

This product is an excellent option for those who want to experience the full benefits of CBD and THC. Moonwlkr’s Strawberry Tincture is a full-spectrum tincture that contains both CBD and THC. This product is designed to provide the benefits of both cannabinoids in one convenient product. Cannabis companies are working hard to make the most out of oils and tinctures. Making them the preferred cannabis product for many THC enthusiasts. And nowadays that cannabis is legal in multiple states, buying legal THC products online is extremely easy.

When deciding which cannabinoid to use for sleep, it’s important to consult with a doctor or healthcare professional who can provide recommendations based on your personal needs. There are a variety of cannabinoids found in cannabis that can be used to improve sleep. While long-term studies on smoking weed and the prevalence of lung cancer do not exist yet, researchers believe there could be a correlation between lung cancer and smoking weed. Indica plants are generally shorter and bushier, and are thought to produce a relaxing, sedative effect. Sativa plants, on the other hand, are taller and thinner, and are thought to produce a more energizing, uplifting effect.

How Does Marijuana Affect a Person’s Life?

Researchers hypothesized the increase in simultaneous use seen among those aged 21 and older could be due to greater availability and opportunity to access cannabis though legal supply chains in states with the laws in place. Typically, recreational cannabis is only legal for those aged 21 and older. This month, Missouri became the latest state to legalize recreational cannabis while New York state issued its first marijuana dispensary licenses in late November. In total, 21 states, Washington D.C., and Guam have legalized recreational marijuana.

Researchers at the University of Copenhagen’s Faculty of Science have modified a yeast cell to sense the active substances in cannabis and get it to turn red when it does. The result paves the way for more actors to discover new medicinal substances and for a new type of drug test that can be done with a smartphone. Other plaintiffs in the challenge have pursued psilocybin therapy illegally after being denied an exemption or waiting for more than a year without a response. Like Is HHC Legal In Europe? Where to buy HHC in Europe. Hartle, several of the plaintiffs have a terminal cancer diagnosis, while others have conditions that includemajor depressive disorder, anxiety and addiction. Compared with the period before recreational cannabis legalization, simultaneous use increased from 9.2 percent to 10.4 percent among those aged 21 through 30. For those aged 31 to 40, prevalence rose from 5 to 6 percent, while for adults between the ages 41 and 50, simultaneous use rose from 3 percent to 4.7 percent.

No medications are currently available to treat marijuana use disorder, but behavioral support has been shown to be effective. Examples include therapy and motivational incentives (providing rewards to patients who remain drug-free). Continuing Vapes, Tinctures, Topicals, And Edibles: What’S The Best Way To Take CBD? research may lead to new medications that help ease withdrawal symptoms, block the effects of marijuana, and prevent relapse. An overdose occurs when a person uses enough of the drug to produce life-threatening symptoms or death.

Can Cannabis And Hemp-Infused Beverages Replace Your Boozy Drinking Habits?

Drinking and smoking tobacco together raises the risk of cancer many times more than drinking or smoking alone. Other lab studies have found that marijuana can make cancer cells grow faster. Marijuana-based products can be smoked, vaped, eaten or drunk to obtain a ‘high’ or used as a relaxant. Some people also use ‘street’ marijuana to relieve the symptoms of various illnesses.

Smoking marijuana is the most harmful way of using cannabis because it directly affects your lungs. You’ll lower your risk of marijuana-related health problems by not starting to use marijuana until after 25 years. People with a life-limiting condition can use ‘street’ marijuana with a medical certificate from their doctor or nurse practitioner. Marijuana contains active ingredients called cannabinoids, including THC and CBD .